Tranexamic Acid
Tranexamic Acid is an anti-fibrinolytic. It works by preventing the breakdown of blood clots to control excessive bleeding during periods, or after surgery.
Mechanism of action
Prevents clot dissolution hence controls excessive blood loss.
Dose
500mg orally 3-4 times a day
650mg orally twice daliy BD
1 gram bolus in 100ml normal saline over 10 minutes (slow intravenous push) 8th hourly
500mg in 100ml of normal saline IV 8th hourly.
( do not exceed a total of 3 grams/day)
Uses
1) Menorrhagia - 1st line non hormonal therapy
Uterine Fibroids
Adenomyosis
DUB
Puberty Menorrhagia
Post IUCD
Endometriosis
2) Haemorrrhagic shock and PPH
3) Excessive Intraop Bleeding in Obstetrics and Gynecology
4)Threatened Abortion and APH
5) Nose bleed
6) After Tooth removal
7) Skin hyperpigmentation
8) Following prostate surgery
Contraindications
- If allergic to tranexamic acid
- kidney diseases
- h/o convulsions or fits
- blood disorders
- smokers
- morbid obesity
- h/o gastric ulcers
- dialysis patients
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