Tranexamic Acid

 Tranexamic Acid is an anti-fibrinolytic. It works by preventing the breakdown of blood clots to control excessive bleeding during periods, or after surgery.

Mechanism of action

Prevents clot dissolution hence controls excessive blood loss.

Dose

500mg orally 3-4 times a day

650mg orally twice daliy BD

1 gram bolus in 100ml normal saline over 10 minutes (slow intravenous push) 8th hourly

500mg in 100ml of normal saline IV 8th hourly.

( do not exceed a total of 3 grams/day)

Uses

1) Menorrhagia - 1st line non hormonal therapy
Uterine Fibroids
Adenomyosis
DUB
Puberty Menorrhagia
Post IUCD
Endometriosis

2) Haemorrrhagic shock and PPH

3) Excessive Intraop Bleeding in Obstetrics and Gynecology

4)Threatened Abortion and APH

5) Nose bleed

6) After Tooth removal

7) Skin hyperpigmentation

8) Following prostate surgery

Contraindications

  • If allergic to tranexamic acid
  • kidney diseases
  • h/o convulsions or fits
  • blood disorders
  • smokers
  • morbid obesity
  • h/o gastric ulcers
  • dialysis patients

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