Tranexamic Acid
Tranexamic Acid is an anti-fibrinolytic. It works by preventing the breakdown of blood clots to control excessive bleeding during periods, or after surgery. Mechanism of action Prevents clot dissolution hence controls excessive blood loss. Dose 500mg orally 3-4 times a day 650mg orally twice daliy BD 1 gram bolus in 100ml normal saline over 10 minutes (slow intravenous push) 8th hourly 500mg in 100ml of normal saline IV 8th hourly. ( do not exceed a total of 3 grams/day) Uses 1) Menorrhagia - 1st line non hormonal therapy Uterine Fibroids Adenomyosis DUB Puberty Menorrhagia Post IUCD Endometriosis 2) Haemorrrhagic shock and PPH 3) Excessive Intraop Bleeding in Obstetrics and Gynecology 4)Threatened Abortion and APH 5) Nose bleed 6) After Tooth removal 7) Skin hyperpigmentation 8) Following prostate surgery Contraindications If allergic to tranexamic acid kidney diseases h/o convulsions or fits blood disorders smokers morbid obesity h/o gastric ulcers dialysis patients